It’s worth the warning that this doesn’t always work. There are lots of moving parts and occasionally there will be breaking changes, regressions, and other incompatibilities that might pop up over time that can make this approach not always work for all bindings. But most of the time it does as the core is pretty stable in most of the ways that matter so it’s good advice. Just not always guaranteed to work in all circumstances.
Beware that Synology has dropped support for USB devices, as I understand it, so openHAB on the Synology may not be able to access the Conbee stick anyway with that sort of deployment. There are ways to host the stick on one machine and expose it for integration over the network (see Share Z-wave dongle over IP (USB over IP using ser2net / socat ) guide) which might work but frankly, I only see people on the forum who have troubles running openHAB on Synology or QNAP.
OH will run very well on that NUC. Most users tend to use an RPi with openHABian which could be another option.