Personally, I favour MQTT over any proproetary solution like bindings whenever possible, as I find it more flexible, less worrisome with major openHAB version changes where dedicated bindings often lag behind, and with MQTT being controller agnostic.
With the last point also meaning, yes, any Python bridge solution publishing to MQTT will also be able to be received by any controller - Home Assistant, FHEM, Jeedom, Supla … as well as openHAB or any other controller supporting MQTT.
I only briefly looked at the bridge repository, and with you being inexperienced with both Python and MQTT I’d strongly advice to initially test installing the bridge on a separate Raspberry Pi. With an MQTT broker I’d recommend installing Mosquito, especially if you are using openHABian on another Pi. Also an MQTT monitoring tool will be very helpful to understand MQTT messages, with the most popular being MQTT Explorer. With MQTT Explorer’s current uncertain future though, also want to mention others like MQTTX, MQTTAnalyzer, mqttk etc.
Install the Python bridge on a RPi and familiarise yourself with the MQTt message the bridge publishes. Then the integration into openHAb with the MQTT binding should become a lot clearer.