That’s the method i’ve been using for both my zwave and zigbee sticks and haven’t had any issues except with the zigbee stick where I needed to set it to 57600 baud for it to work reliably. I also had to use this guide to “sticky” my USB sticks to a /dev device (/dev/ttyUSB-ZWave and /dev/ttyUSB-Zigbee in my case) on the pi because once I added the second one it was a toss up which one would get assigned ttyUSB0 and ttyUSB1 on a reboot which messed up my bindings.
