My ZWave network is about the same size as yours (I stopped counting so don’t have the exact numbers).
I’m using the OH2 ZWave binding (the development version, actually) on a Pi3+RaZberry with no performance issues for well over a year.
Note ZWave network healing is not available in standard ZWave2 binding as it used to be in OH1 binding but it’s back in the development version.
I do need to resort to shutdown OH and fire up Z-Way every now and then to clean up some zwave things after I changed/extended the network, but other than that, it’s pretty stable and fast.
Well to speak frankly, the most recent version has a severe problem resulting in lockup after some hours of runtime, but I’m confident @chris will resolve that soon.