No and yes. As Bruce indicates, you can’t really run OH on an RPi 0. There isn’t enough RAM. But yes, you can run multiple OH instances and federate them using the Marketplace MQTT Event Bus.
However, that probably isn’t the best way to accomplish this, especially given that OH doesn’t have good support for BT devices. The Bluetooth binding pretty much only supports a couple of beacons. So OH is probably not going to be your best choice for controlling the actuators. You will likely need to find a Python script or something like that on github to actually control them.
Then with that in hand and working you can set up communication between them and a single OH, MQTT is a popular choice. You can almost certainly run such a Python script on an RPi 0 without problem.
Your big task is going to be finding something written to interact with and control your specific devices. Once you have that the best over all approach may become more apparent.