Just to answer my own question and to provide a solution to some requests here how to add multiple RegexFilters to the appender:
You can even combine them with other filter types like the following:
<Appenders>
<RollingFile fileName="${sys:openhab.logdir}/critical.log" filePattern="${sys:openhab.logdir}/critical.log.%i.gz" name="CRITICAL">
<PatternLayout pattern='["%d{yyyy-MM-dd HH:mm:ss.SSS}","%p","%c{3}","%enc{%m}{JSON}"%ex{NONE}],%n'/>
<Filters>
<RegexFilter regex=".*Attempting to send a state update of an item which doesn't exist.*" useRawMsg="false" onMatch="DENY" onMismatch="NEUTRAL"/>
<RegexFilter regex=".*Cannot determine master volume level - assuming 100.*" useRawMsg="false" onMatch="DENY" onMismatch="NEUTRAL"/>
<RegexFilter regex=".*whatever.*" useRawMsg="false" onMatch="DENY" onMismatch="NEUTRAL"/>
<ThresholdFilter level="WARN" onMatch="ACCEPT" onMismatch="DENY"/>
</Filters>
<Policies>
<OnStartupTriggeringPolicy/>
<SizeBasedTriggeringPolicy size="1 MB"/>
</Policies>
<DefaultRolloverStrategy max="7"/>
</RollingFile>
...
<Appenders/>
Important is the order of the filter and that either onMatch or onUnmatch is set to NEUTRAL
Furthermore this log file is quick&dirty JSON-stylish in case you might want to load it into a widget.
Thanks again Rich - to me, this solution is more elegant.
EDIT:
For true JSON-based log file simply replace
<PatternLayout .../>
with
<JsonTemplateLayout eventTemplateUri="classpath:EcsLayout.json"/>