I’m not familiar with OpenThread so I can comment. The CC2531 stick can be connected to all the Zigbee devices listed in this link.
Also check the top of the link to see how you can add devices that are not supported and the devices that are listed as not yet supported.
Note: if considering the CC2531 this is for zigbee only, you will need another USB stick for Zwave. On the link posted, see the right side 7th from the top, see “Getting Started” for what’s needed and instruction to setup zigbee2mqtt.