If you run socat on the machine with openHAB you configure it like a normal serial port and it will most likely already work with any binding.
There is also built-in support in openHAB for so called RFC2217 ports.
In that case you only run ser2net and don’t use socat but specify the serial port as rfc2217://hostname:port
In OH 2.5.5 there are some improvements to get such ports working with more bindings. I.e.:
- most bindings now use the serial transport (which is required for this) (#7573)
- the UIs no longer limit what serial port can be configured (#7625)
Besides that some bindings such as Z-Wave need a few changes for the built-in RFC2217 support to work. But these are simple changes.