Hi Stefan,
I have two knxd instances running. One with the USB Adapter from Busware (busware.de) and one with an IP Gateway from Hager. Both work fine.
The busware USB TPUART adapter is on a PI4.
With both instances I can connect using the openhab binding. I just posted parts of the knx.things configuration here: KNX Binding stopped working after power loss - #5 by Jonas88
Best regards
Marco