You configure ser2net on another machine like described in Share Z-wave dongle over IP (USB over IP using ser2net / socat ) guide. You then won’t need to configure socat because openHAB will take care of that. Instead of a normal serial port /dev/ttyUSB0 you configure a rfc2217 port: rfc2217://hostname:port
It’s really simple and you can even run ser2net in a Docker container. That’s how I tested it. 